Their best years are still ahead.

ESB-01 is the first daily blend for dogs formulated from human longevity research and held to pharmaceutical-grade standards.

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7+

Title

Scientific Advisors

Across veterinary medicine and longevity research

FDA

Title

Registered Facilities

Manufactured in FDA and GMP Certified facilities with mandatory third-party testing on every batch

10+

Title

Clinical Trials

Ongoing and completed studies validating the compounds in ESB-01 at human-grade standards

34+

Title

Peer-Reviewed Studies

The largest body of longevity research ever applied to compounds in a dog supplement

Their best years are still ahead.

ESB-01 is the first daily blend for dogs formulated from human longevity research and held to human standards.

Shop ESB-01

Take the quiz →

7+

....................................

Scientific Advisors

Scientific advisors across veterinary medicine and longevity research

FDA

....................................

Registered Facilities

Registered and GMP-certified facilities

10+

....................................

Clinical Trials

Ongoing and completed clinical trials

34+

....................................

Peer-Reviewed Studies

Peer reviewed across all compounds 

ESB-01  Everyday Super Blend

Reactive care starts too late. ESB-01 doesn’t.

ESB-01 targets the mechanisms behind cellular decline before you see the signs

Title

THIS IS WHAT LOVE LOOKS LIKE

Renewal

Energy

Mood and Cognition

Joint Health

* Based on a clinical study with 41 dogs aged 5 to 14 using ESB-01

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Increase in mitophagy flux (LC3-II/LC3-I ratio) vs. placebo 

Increase in skeletal muscle NAD+ concentration vs placebo

Improvement in Canine Cognitive Dysfunction Rating (CCDR) score vs placebo 

Reduction in serum C-reactive protein vs placebo

ESB-01 Everyday Super Blend

Reactive care starts too late. ESB-01 doesn’t.

ESB-01 targets the mechanisms behind cellular decline before you see the signs

Older isn't the same as aging. One is a number. One is a mechanism.

Most owners measure their dog's age in years. But the biology of aging is measured in something else entirely. Learn what's actually happening and what you can do about it.

Discover

Older isn't the same as aging. One is a number. One is a mechanism.

Most owners measure their dog's age in years. But the biology of aging is measured in something else entirely. Learn what's actually happening and what you can do about it.

SCIENCE / Longevity 101

ESB-01 Everyday Super Blend

Reactive care starts too late. ESB-01 doesn’t.

ESB-01 targets the mechanisms behind cellular decline before you see the signs

Start Now

NAD+
(via NMN)

Fuels NAD+ production for the body’s energy output

                                 QUERCETIN

Calms inflammation for faster recovery and mobility

VITAMIN E

Shields cells from oxidative damage

                              PQQ

Regenerates mitochondrial function

          L-CARNITINE

Transports fatty acids for ATP production

                                 SPERMIDINE

Triggers cellular self-cleaning cycle

     PTEROSTILBENE

Activates cellular repair signals

                             COQ 10

Drives ATP synthesis in the ETC

"We're not making them immortal, but that rate of aging will be slower, which means the pet will be in a healthier state for longer"

"Boosting NAD⁺ levels increases insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan"

"Research to help dogs live longer, healthier lives."

"It's not a quick trick. It's just taking a basic, foundational understanding of how aging and biology works, and doing better preventive medicine"

"Early studies hint at improvements in memory, metabolism, and physical function"

"Nutraceutical agents are increasingly recognized for their capacity to attenuate systemic inflammation, preserve muscle mass, and support metabolic resilience."

Older isn't the same as aging. One is a number. One is a mechanism.

Most owners measure their dog's age in years. But the biology of aging is measured in something else entirely. Learn what's actually happening and what you can do about it.

Discover

SCIENCE / Longevity 101

CLINICALLY RECOMMENDED FORMULATIONS

Formulations that provide sustained support using key scientifically and clinically studied ingredients

35 LBS AND BELOW

ESB-01 Everyday Super Blend

NAD+ (via β-Nicotinamide Mononucleotide)

Enzymatic fermentation origin (nicotinamide + D-ribose pathway), CAS 1094-61-7; stabilised anhydrous form, >98% purity by HPLC

Pterostilbene

Pterocarpus marsupium (heartwood) extract; trans-isomer, CAS 537-42-8; >99% purity by HPLC; dimethylated stilbenoid analog

Quercetin

Sophora japonica L. flower bud extract, CAS 6151-25-3; standardised to >95% quercetin aglycone by HPLC; flavonoid isolate

Spermidine

Trihydrochloride Triticum destivum (wheat germ) extract, CAS 334-50-9; standardized polyamine fraction, >98% spermidine by
HPLC

Coenzyme Q10

Saccharomyces cerevisiae fermentation origin, CAS 303-98-0; ubiquinone form, >99% purity by HPLC; lipid-soluble benzoquinone

L-Carnitine

Bacterial fermentation origin, CAS 36687-82-8; tartrate-complexed form, > 97% purity by HPLC

Pyrroloquinoline Quinone

Hyphomicrobium sp. fermentation origin, CAS 122628-50-6; disodium salt form, >99% purity by HPLC; redox cofactor isolate

d-Alpha-Tocopherol (Vitamin E)

Non-GMO sunflower oil distillate, CAS 59-02-9; natural d-isomer form, >96% purity by HPLC

Full Ingredient List

β-Nicotinamide Mononucleotide, Pterostilbene, Quercetin, Spermidine, Coenzyme Q10, L-Carnitine, Pyrroloquinoline Quinone, d-Alpha-Tocopherol, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, Hypromellose (capsule shell).

Shop ESB-01

36 LBS AND ABOVE

GSB-02 Grande Super Blend

NAD+ (via β-Nicotinamide Mononucleotide)

Enzymatic fermentation origin (nicotinamide + D-ribose pathway), CAS 1094-61-7; stabilised anhydrous form, >98% purity by HPLC

Pterostilbene

Pterocarpus marsupium (heartwood) extract; trans-isomer, CAS 537-42-8; >99% purity by HPLC; dimethylated stilbenoid analog

Resveratrol

Polygonum cuspidatum (Japanese knotweed) extract; trans-isomer, CAS 501-36-0; >98% trans-resveratrol by HPLC; stilbenoid polyphenol isolate

L-Carnitine

Bacterial fermentation origin, CAS 36687-82-8; tartrate-complexed form, > 97% purity by HPLC

Coenzyme Q10

Saccharomyces cerevisiae fermentation origin, CAS 303-98-0; ubiquinone form, >99% purity by HPLC; lipid-soluble benzoquinone

Glutathione

Saccharomyces cerevisiae fermentation origin; CAS 70-18-8; reduced L-glutathione form, >98% purity by HPLC; tripeptide antioxidant isolate

Fisetin

Toxicodendron vernicifluum (Japanese wax tree) extract; CAS 528-48-3; standardized to >98% fisetin by HPLC; flavonoid isolate

Pyrroloquinoline Quinone

Hyphomicrobium sp. fermentation origin, CAS 122628-50-6; disodium salt form, >99% purity by HPLC; redox cofactor isolate

Spermidine

Trihydrochloride Triticum destivum (wheat germ) extract, CAS 334-50-9; standardized polyamine fraction, >98% spermidine by
HPLC

d-Alpha-Tocopherol (Vitamin E)

Non-GMO sunflower oil distillate, CAS 59-02-9; natural d-isomer form, >96% purity by HPLC

Full Ingredient List

β-Nicotinamide Mononucleotide, Pterostilbene, Quercetin, Spermidine, Coenzyme Q10, L-Carnitine, Pyrroloquinoline Quinone, d-Alpha-Tocopherol, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, Hypromellose (capsule shell).

Shop GSB-02

Shellfish-free

Dairy-free

No binders

Vegan

Gluten-free

Cattle-free

No fillers

FDA-Approved labs

Poultry-free

Allergen-free

No preservatives

Third-party tested

CLINICALLY RECOMMENDED FORMULATIONS

CLINICALLY RECOMMENDED PEPTIDES

Formulations that provide sustained support using key scientifically and clinically studied ingredients

35 LBS AND BELOW

ESB-01

Everyday Super Blend

SHOP now

Starting at $60.00 per month

36 LBS AND ABOVE

GSB-02

Grande Super Blend

Starting at $50.15 per month

36 LBS AND ABOVE

GSB-02

Grande Super Blend

SHOP now

Starting at $90.00 per month

Shellfish-free

Gluten-free

Dairy-free

Poultry-free

Cattle-free

Allergen-free

No preservatives

Vegan

No binders

No fillers

FDA-Approved labs

Third-party tested

Real dogs, real results.

See how dog parents are changing their dog's lives with ESB-01.

Backed by science. Proven by real results.

See how dog parents are changing their dog's lives with ESB-01.

Bloo (7 year old French Bulldog)

Honestly, I thought this was just another supplement. But after a month Bloo is up before me waiting by the door for our morning walk. I was hoping it would help her but I wasn't expecting that BIG of an improvement.

- Laura F.

Flynn (10 year old Labradoodle)

I used to juggle about 3 different supplements for Flynn but this replaced them all. Within two weeks Flynn had more energy, his coat got better, and his gut problems went away. Overall he just seems years younger. I can't thank you guys enough!!!

- Christina E.

Poppy (9 year old Chow Chow)

Poppy was slowing down and our walks were getting shorter. I started adding this to her food every morning. By week 3 it was like she was 8 again! She's walking the block multiple times and tries to chase squirrels again. Seeing her happy makes me so happy!! I honestly didn’t expect it to work this fast.

- Nora Z.

Taco (10 year old unknown mix)

The everyday super blend is the first thing I haven’t had to hide in peanut butter. Taco's joints have gotten A LOT better and he's more healthy now than he was 2 years ago. I feel like I got my puppy back. THANK YOU for whatever magic you've made.

- Oyuka F.

Lolla (12 year old Pomeranian mix)

We've been experimenting with different joint chews and fish oils but this is the only one that worked. It took about a month, but one day I realized Lolla's dry patches on her ears have gotten softer. She already had a shiny coat, but WOW, her coat is feeling silkier. People think she is much younger than she is. 

- Krysha M.

Questions?
We're here to help.

What's the difference between ESB-01 and GSB-02?

Both are clinically validated daily longevity peptides built on the same science, but they're formulated for different sized dogs. ESB-01 is made for dogs 35 lb / 16 kg and under, while GSB-02 is made for larger and giant breeds above that weight.


The difference in is more than just the dose: Large dogs age faster and through different biology, so GSB-02 keeps the core longevity compounds that benefit every dog and adjusts the rest for large-breed physiology.

What benefits can I expect to see?

Most owners notice increased energy levels, joint health and coat in as little as 2 to 3 weeks. Other longer term benefits like cardiovascular health and gut immune function may take a little longer. 

 

As long as you continue with the daily intake, the longevity peptide is doing its work inside to program, sustain, and enhance your dog's health.

How do I serve these longevity peptides? 

Open 1 capsule and pour over breakfast every morning.

Can it be taken with other supplements or medication?

ESB-01 and GSB-02 may be layered or used alone. We've seen it used safely alongside antibiotics, prebiotics, probiotics, fish oils, and other supplements.

What does it taste like?

ESB-01 and GSB-02 are flavorless to blend seamlessly into your dog’s regular meal.

Is it safe for dogs with sensitive stomachs?

Yes, it is made with human-grade ingredients and without fillers. In fact, the ESB-01 and GSB-02 are generally easier on the stomach than many traditional supplements.

Is it safe for my dog's kidney and liver?

No adverse effects on the kidney or liver have been reported at the recommended daily serving. 

Questions?
We're here to help.

What's the difference between ESB-01 and GSB-02? 

Both are clinically validated daily longevity peptides built on the same science, but they're formulated for different sized dogs. ESB-01 is made for dogs 35 lb / 16 kg and under, while GSB-02 is made for larger and giant breeds above that weight.


The difference in is more than just the dose: Large dogs age faster and through different biology, so GSB-02 keeps the core longevity compounds that benefit every dog and adjusts the rest for large-breed physiology.

What benefits can I expect to see?

Most owners notice increased energy levels, joint health and coat in as little as 2 to 3 weeks. Other longer term benefits like cardiovascular health and gut immune function may take a little longer. 

 

As long as you continue with the daily intake, the longevity peptide is doing its work inside to program, sustain, and enhance your dogs health.

How do I serve these longevity peptides? 

Open 1 capsule and pour over breakfast every morning.

Can it be taken with other supplements or medication?

ESB-01 and GSB-02 may be layered or used alone. We've seen it used safely alongside antibiotics, prebiotics, probiotics, fish oils, and other supplements.

What does it taste like?

ESB-01 and GSB-01 are flavorless to blend seamlessly into your dog’s regular meal.

Is it safe for dogs with sensitive stomachs?

Yes, it is made with human-grade ingredients and without fillers. 

 

In fact, the ESB-01 and GSB-02 are generally easier on the stomach than many traditional supplements.

Is it safe for my dog's kidney and liver?

No adverse effects on the kidney or liver have been reported at the recommended daily serving. 

Our Science

Our Science

Our Science

How we decide what goes in, what stays out and why it matters. 

How we decide what goes in, what stays out and why it matters. 

How we decide what goes in, what stays out and why it matters. 

Read More

Read More

Read More

Aging is a mechanism. Not a sentence.

Aging is a mechanism. Not a sentence.

Address it at the source with ESB-01.

Address it at the source with ESB-01.

Shop ESB-01

Aging is a mechanism. 

Aging is a mechanism. Not a sentence.

Address it at the source with ESB-01.

Address it at the source with ESB-01.

Shop ESB-01

Shop ESB-01

Big dogs need more than a big dose.

Big dogs need more than a big dose.

Our flagship blend, formulated for larger dogs.

Our flagship blend, formulated for larger dogs.

Shop GSB-02

Shop GSB-02

Big dogs need more than a big dose.

Big dogs need more than a big dose.

Our flagship blend, formulated for larger dogs.

Our flagship blend, formulated for larger dogs.

Shop GSB-02